TROMBOSIS EXPERIMENTAL

TROMBOSIS EXPERIMENTAL


Directora: Dra. Mirta Schattner
Investigador Superior – CONICET
mschattner@hotmail.com
VER CV 

Co-Director: Dr. Eugenio Antonio Carrera Silva
Investigador Adjunto – CONICET
carrerasilva@yahoo.com.ar
VER CV

INVESTIGADORES:

  • Nancy Charo. Investigadora Asistente de CONICET (Dir: Dra. Schattner)
  • Paola D´Atri.Investigadora Adjunta-CONICET
  • Julia Etulain. Investigadora Adjunta-CONICET
  • Roberto G. Pozner.Investigador Adjunto-CONICET

BECARIOS DOCTORALES Y POSTDOCTORALES:

  • Juan Manuel Ortiz Wilczyñski. Becario Doctoral de CONICET (Dir: Dr. Carrera-Silva)
  • Mariel Olexen. Becaria Doctoral CONICET (Dir. Dr. Carrera-Silva)
  • Aída Oryza López Ortiz. Becaria Doctoral ANPCyT (Co-Dir. Dr. Carrera-Silva).
  • Camila Sofía Rodriguez. Becaria Doctoral ANPCyT (Dir. Dr. Schattner/Co-Dir Paola D´Atri)
  • Paula Oneto. Becaria Doctoral CONICET (Dir. Julia Etulain)

TESINISTAS DE GRADO Y MAESTRIA

  • Rosario Juchazara. Maestría de Biología Molecular Médica. FFyB, UBA (Dir. Dra. Schattner/Co-Dir Dra. Charo)
  • Julian Hernan de Cortéz Maestría de Biología Molecular Médica. FFyB, UBA (Dra. Schattner/Co-Dir Dra. Charo)
  • Yvan Doctorovich, Tesis de grado FCEyN, UBA (Roberto Pozner)

LÍNEAS DE INVESTIGACIÓN

FISIOPATOLOGIA DE LA MEGACARIO/TROMBOPOYESIS Y FUNCION PLAQUETARIA

  • Rol de los TLR en la megacario/trombopoyesis.(Schattner/Datri)
  • Efectos del nitroxilo (HNO) sobre la función plaquetaria.(Pozner)

CROSSTALK ENTRE LA INMUNIDAD INNATA, COAGULACION E INFLAMACIÓN

  • Rol de los receptores TAM y la respuesta Th2 inmunoprotectora en la esclerosis múltiple. (Carrera Silva)
  • Histiocitosis de células de Langerhans y evaluación de las vías de señalización activadas por los receptores tirosina quinasa TAM. (Carrera Silva)
  • Activación de la vía TAM y el papel de monocitos/macrófagos en enfermedades inflamatorias intestinales. (Carrera Silva)
  • Plasticidad de los macrófagos como target para modular respuestas efectoras en infección. (Carrera Silva)
  • Caracterización del efecto de nanopartículas de arqueobaterias en el endotelio vascular (Schattner/Charo)
  • Rol de las trampas extracelulares de ADN en la patogénesis de la sinovitis crónica hemofílica en pacientes tratados con PRP. (Etulain)

PUBLICACIONES (más relevantes)

  1. PRP in wound healing applications. Oneto P, Etulain J. Platelets. 2021 Feb 17;32(2):189-199. doi: 10.1080/09537104.2020.1849605.
  2. Inhibition of Fenton reaction is a novel mechanism to explain the therapeutic effect of intra-articular injection of PRP in patients with chronic haemophilic synovitis. Caviglia H, Daffunchio C, Galatro G, Cambiaggi G, Oneto P, Douglas Price AL, Landro ME, Etulain J. Haemophilia. 2020 Jul;26(4):e187-e193. doi: 10.1111/hae.14075.
  3. GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection. Ortiz Wilczyñski JM, Olexen CM, Errasti AE, Schattner M, Rothlin CV, Correale J, Carrera Silva EA. PLoS Pathog. 2020 Dec 21;16(12):e1009176. doi: 10.1371/journal.ppat.1009176
  4. Editorial: Platelets and Immune Responses During Thromboinflammation. Schattner M, Jenne CN, Negrotto S, Ho-Tin-Noe B. Front Immunol. 2020 May 28;11:1079. doi: 10.3389/fimmu.2020.01079.
  5. Platelet Toll-Like Receptors Mediate Thromboinflammatory Responses in Patients With Essential Thrombocythemia. Marín Oyarzún CP, Glembotsky AC, Goette NP, Lev PR, De Luca G, Baroni Pietto MC, Moiraghi B, Castro Ríos MA, Vicente A, Marta RF, Schattner M, Heller PG. Front Immunol. 2020 Apr 30;11:705. doi:10.3389/fimmu.2020.00705
  6. Phosphatidylserine trapped in the net: a new therapeutic target for the ischemic stroke? Federico Rodriguez Lucci and Mirta Schattner. EBioMedicine. 2020 Apr;54:102713. doi: 10.1016/j.ebiom.2020.102713. Epub 2020 Apr 5.
  7. Anticoagulants Interfere With the Angiogenic and Regenerative Responses Mediated by Platelets. Oneto P, Zubiry PR, Schattner M, Etulain J. Front Bioeng Biotechnol. 2020 Mar 20;8:223. doi: 10.3389/fbioe.2020.00223
  8. Editorial: Viral Evasion Mechanisms of the Host Response. Gómez RM*, Carrera Silva EA*, Abrahão JS*, Lim SP*, Siddiqui A*. Front Cell Infect Microbiol. 2020 Feb 28;10:90. doi: 10.3389/fcimb.2020.00090. *Estos autores tuvieron igual contribución
  1. Platelets and Extracellular Traps in Infections. Ricardo M Gómez, Aída O López Ortiz, Mirta Schattner. Platelets, 1-9 2020 Jan 26 doi:10.1080/09537104.2020.1718631.
  2. Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice. Carestia A, Mena HA, Olexen CM, Ortiz Wilczyñski JM, Negrotto S, Errasti AE, Gómez RM, Jenne CN, Carrera Silva EA*, Schattner M*. Cell Reports. 2019 Jul 23;28(4):896-908.e5. doi: 10.1016/j.celrep.2019.06.062. *Ambos autores comparten la última autoría.
  3. Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR. Nowak W, Grendas LN, Sanmarco LM, Estecho IG, Arena ÁR, Eberhardt N, Rodante DE, Aoki MP, Daray FM*, Carrera Silva EA*, Errasti AE*. EBioMedicine. 2019 Dec;50:290-305. doi: 10.1016/j.ebiom.2019.10.063. *Estos autores comparten la última autoría.
  4. Activation of toll-like receptors 2 and 4 on CD34+ cells increases human megakaryo/thrombopoiesis induced by thrombopoietin. D’Atri LP, Rodríguez CS, Miguel CP, Pozner RG, Ortiz Wilczyñski JM, Negrotto S, Carrera-Silva EA, Heller PG, Schattner M. J Thromb Haemost. 2019 Dec;17(12):2196-2210. doi:10.1111/jth.14605.
  5. Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity. Ferrer MF, Thomas P, López Ortiz AO, Errasti AE, Charo N, Romanowski V, Gorgojo J, Rodriguez ME, Carrera Silva EA*, Gómez RM*. Front Immunol. 2019 Oct 22;10:2499. doi: 10.3389/fimmu.2019.02499. *Ambos autores comparten la última autoría
  6. Ceramide 1-Phosphate Protects Endothelial Colony-Forming Cells From Apoptosis and Increases Vasculogenesis In Vitro and In Vivo. Mena HA, Zubiry PR, Dizier B, Mignon V, Parborell F, Schattner M, Boisson-Vidal C, Negrotto S. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):e219-e232. doi: 10.1161/ATVBAHA.119.312766.
  7. Role of neutrophils in CVB3 infection and viral myocarditis. Rivadeneyra L, Charó N, Kviatcovsky D, de la Barrera S, Gómez RM, Schattner M. J Mol Cell Cardiol. 2018 Dec;125:149-161. doi: 10.1016/j.yjmcc.2018.08.029.
  8. Platelet TLR4 at the crossroads of thrombosis and the innate immune response. Schattner M. J Leukoc Biol. 2018 Dec 4. doi: 10.1002/JLB.MR0618-213R
  9. Acidic preconditioning of endothelial colony-forming cells (ECFC) promote vasculogenesis under proinflammatory and high glucose conditions in vitro and in vivo. Mena HA, Zubiry PR, Dizier B, Schattner M, Boisson-Vidal C, Negrotto S. Stem Cell Res Ther. 2018 May 2;9(1):120. doi: 10.1186/s13287-018-0872-7.
  10. NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection. Paroli AF, Gonzalez PV, Díaz-Luján C, Onofrio LI, Arocena A, Cano RC, Carrera-Silva EA, Gea S. Front Immunol. 2018 May 3;9:913. doi: 10.3389/fimmu.2018.00913
  11. An optimised protocol for platelet-rich plasma preparation to improve its angiogenic and regenerative properties. Etulain J, Mena HA, Meiss RP, Frechtel G, Gutt S, Negrotto S, Schattner M. Sci Rep. 2018 Jan 24;8(1):1513. doi: 10.1038/s41598- 018-19419-6.
  12. CD207+CD1a+ cells circulate in pediatric patients with active Langerhans cell histiocytosis. Carrera Silva EA, Nowak W, Tessone L, Olexen CM, Ortiz Wilczyñski JM, Estecho IG, Elena G, Errasti AE, Rosso DA. Blood. 2017 Oct 26;130(17):1898- 1902. doi: 10.1182/blood-2017-05-782730. Comentario Editorial Inside Blood (Blood. 2017 Oct 26;130(17):1874-1875)
  13. Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions. Kviatcovsky D, Rivadeneyra L, Balboa L, Yokobori N, López B, Ritacco V, Schattner M, Sasiain MDC, de la Barrera S. Mediators Inflamm. 2017;2017:2810606. doi: 10.1155/2017/2810606.
  14. Nucleosomes and neutrophil extracellular traps in septic and burn patients. Kaufman T, Magosevich D, Moreno MC, Guzman MA, D'Atri LP, Carestia A, Fandiño ME, Fondevila C, Schattner M. Clin Immunol. 2017 Oct;183:254-262. doi: 10.1016/j.clim.2017.08.014.
  15. Platelet toll-like receptors in thromboinflammation. DAtri LP, Schattner M. Front Biosci (Landmark Ed). 2017 Jun 1;22:1867-1883.